Genomic Imprinting: An Obsession with Depilatory Mice
نویسندگان
چکیده
Excessive grooming in mice has been promoted as a model of human obsessive-compulsive disorders. A recent paper adds Grb10 to the list of genes with effects on behavioral hair loss, with the added twist that this time the gene is imprinted.
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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ورودعنوان ژورنال:
- Current Biology
دوره 21 شماره
صفحات -
تاریخ انتشار 2011